| Identification | Back Directory | [Name]
Foliglurax hydrochloride | [CAS]
2133294-96-7 | [Synonyms]
PXT002331
PXT 002331
Foliglurax hydrochloride
Foliglurax monohydrochloride
PXT002331 (monohydrochloride) | [Molecular Formula]
C23H24ClN3O3S | [MOL File]
2133294-96-7.mol | [Molecular Weight]
457.97 |
| Hazard Information | Back Directory | [Uses]
Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM[1]. Antiparkinsonian effect[1]. | [IC 50]
mGlu4: 79 nM (EC50) | [storage]
Store at -20°C | [References]
[1] Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. DOI:10.1021/acs.jmedchem.7b00991
[2] Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423. DOI:10.1080/17460441.2018.1443076 |
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