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2133294-96-7

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2133294-96-7 Structure

2133294-96-7 Structure
IdentificationBack Directory
[Name]

Foliglurax hydrochloride
[CAS]

2133294-96-7
[Synonyms]

PXT002331
PXT 002331
Foliglurax hydrochloride
Foliglurax monohydrochloride
PXT002331 (monohydrochloride)
[Molecular Formula]

C23H24ClN3O3S
[MOL File]

2133294-96-7.mol
[Molecular Weight]

457.97
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 5 mg/mL (10.92 mM)
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM[1]. Antiparkinsonian effect[1].
[IC 50]

mGlu4: 79 nM (EC50)
[storage]

Store at -20°C
[References]

[1] Charvin D, et al. Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4. J Med Chem. 2017 Oct 26;60(20):8515-8537. DOI:10.1021/acs.jmedchem.7b00991
[2] Volpi C, et al. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4. Expert Opin Drug Discov. 2018 May;13(5):411-423. DOI:10.1080/17460441.2018.1443076
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