| Identification | Back Directory | [Name]
R-IMPP | [CAS]
2133832-83-2 | [Synonyms]
R-IMPP
Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl- | [Molecular Formula]
C24H27N3O2 | [MDL Number]
MFCD31544323 | [MOL File]
2133832-83-2.mol | [Molecular Weight]
389.49 |
| Chemical Properties | Back Directory | [Boiling point ]
594.4±50.0 °C(Predicted) | [density ]
1.186±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 1 mg/ml; DMSO: 10 mg/ml | [form ]
A crystalline solid | [pka]
9.14±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 μM). It promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels. (R)-IMPP apparently impairs PCSK9 secretion by causing transcript-dependent inhibition of PCSK9 translation. | [Uses]
R-IMPP (PF-00932239) is an anti-secretagogue of PCSK9 (IC50=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation[1]. | [storage]
Store at -20°C | [References]
[1] Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371 DOI:10.1016/j.chembiol.2016.08.016 |
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