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KUNG94 is a potent and selective Grp94 inhibitor (IC50 = 8 nM). KUNG94 manifests Grp94-selective inhibition in cells and represents a new scaffold_x000D_
for the development of Grp94-selective inhibitors.Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the 90 kDa heat shock protein (Hsp90) family and represents a promising therapeutic target for the treatment of several diseases. |
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