| Identification | Back Directory | [Name]
1H-Indole-2-carbonitrile, 4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1-[(2S)-2-[4-(methylsulfonyl)-1-piperazinyl]propyl]- | [CAS]
2134675-36-6 | [Synonyms]
KO-539
Ziftomenib
ziftomenibum
KO-539 (Ziftomenib, KO 539)
1H-Indole-2-carbonitrile, 4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1-[(2S)-2-[4-(methylsulfonyl)-1-piperazinyl]propyl]- | [Molecular Formula]
C33H42F3N9O2S2 | [MDL Number]
MFCD34574446 | [MOL File]
2134675-36-6.mol | [Molecular Weight]
717.87 |
| Chemical Properties | Back Directory | [Boiling point ]
851.4±75.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
8.03±0.10(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Uses]
Ziftomenib (KO-539) is an orally active menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151)[1]. | [References]
[1] Tao Wu, et al. Substituted inhibitors of menin-mll and methods of use. WO2017161028A1. |
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