| Identification | Back Directory | [Name]
2H-1-Benzopyran-3-carboxamide, N-[3-(4-fluorophenyl)propyl]-7-hydroxy-2-oxo- | [CAS]
2136579-33-2 | [Synonyms]
AKR1B10-IN-1
N-(3-(4-Fluorophenyl)propyl)-7-hydroxycoumarin-3-carboxamide
2H-1-Benzopyran-3-carboxamide, N-[3-(4-fluorophenyl)propyl]-7-hydroxy-2-oxo- | [Molecular Formula]
C19H16FNO4 | [MOL File]
2136579-33-2.mol | [Molecular Weight]
341.33 |
| Chemical Properties | Back Directory | [Boiling point ]
640.8±55.0 °C(Predicted) | [density ]
1.357±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.48±0.20(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells[1]. | [References]
[1] Endo S, et al. Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells [published correction appears in J Med Chem. 2018 Feb 8;61(3):1380] DOI:10.1021/acs.jmedchem.7b00830 |
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