| Identification | Back Directory | [Name]
5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester | [CAS]
213771-32-5 | [Synonyms]
Methyl 5-Bromo-3-methylpicolinate
5-Bromo-3-methylpicolinic acid methyl ester
methyl 3-methyl-5-bromo-2-pyridinecarboxylate
Methyl 5-bromo-3-methyl-pyridine-2-carboxylate
5-BroMo-3-Methylpyridine-2-Carboxylic Acid Methyl
2-Pyridinecarboxylic acid, 5-bromo-3-methyl-, methyl ester
5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester ISO 9001：2015 REACH
Methyl 5-bromo-3-methylpicolinate, 5-Bromo-2-(methoxycarbonyl)-3-methylpyridine | [Molecular Formula]
C8H8BrNO2 | [MDL Number]
MFCD07375126 | [MOL File]
213771-32-5.mol | [Molecular Weight]
230.059 |
| Chemical Properties | Back Directory | [Boiling point ]
302.2±37.0 °C(Predicted) | [density ]
1.503 | [storage temp. ]
Room temperature. | [pka]
-0.17±0.10(Predicted) | [Appearance]
White to yellow Solid | [InChI]
InChI=1S/C8H8BrNO2/c1-5-3-6(9)4-10-7(5)8(11)12-2/h3-4H,1-2H3 | [InChIKey]
KZPOANNAYCXMSH-UHFFFAOYSA-N | [SMILES]
C1(C(OC)=O)=NC=C(Br)C=C1C |
| Hazard Information | Back Directory | [Synthesis]
Step C: Synthesis of methyl 5-bromo-3-methylpyridine-2-carboxylate
5-Bromo-3-methylpyridine-2-carboxylic acid (2.6 g, 12 mmol) was dissolved in N,N-dimethylformamide (20.0 mL) followed by addition of potassium carbonate (4.99 g, 36.1 mmol) and iodomethane (1.50 mL, 24.1 mmol). The reaction mixture was stirred at 80 °C for 40 min. After completion of the reaction, the mixture was extracted with ethyl acetate and water by partitioning. The organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to give methyl 5-bromo-3-methylpyridine-2-carboxylate 2.3 g in yellow solid form in 83% yield. | [References]
[1] Patent: US2013/96144, 2013, A1. Location in patent: Paragraph 0392; 0393
[2] Patent: WO2008/100715, 2008, A1. Location in patent: Page/Page column 34 |
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