| Identification | Back Directory | [Name]
T2AA (hydrochloride) | [CAS]
2138331-07-2 | [Synonyms]
βS-amino-4-(4-hydroxyphenoxy)-3,5-diiodo-benzenepropanol,monohydrochloride | [Molecular Formula]
C15H16ClI2NO3 | [MOL File]
2138331-07-2.mol | [Molecular Weight]
547.56 |
| Hazard Information | Back Directory | [Uses]
T2AA hydrochloride is a non-peptide small molecule PCNA inhibitor T2 amino alcohol (T2AA) that lacks thyroid hormone activity. T2AA hydrochloride inhibits the interaction of PCNA/PIP-box peptide (IC50=~1 μM) and the interaction of PCNA with full-length p21 protein[1]. | [References]
[1] Punchihewa C, et al. Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300. DOI:10.1074/jbc.M112.353201 |
|
|