| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]amino]- | [CAS]
2140807-36-7 | [Synonyms]
Pomalidomide-PEG3-OH
Pomalidomide-NH-PEG2-OH
Pomalidomide-PEG-3-OH,Pomalidomide PEG3 OH,PomalidomidePEG3OH
6-dioxo-3-piperidinyl)-4-[[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]amino]-
2-(2,6-dioxopiperidin-3-yl)-4-((2-(2-(2-hydroxyethoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]amino]- | [Molecular Formula]
C19H23N3O7 | [MDL Number]
MFCD32666563 | [MOL File]
2140807-36-7.mol | [Molecular Weight]
405.4 |
| Chemical Properties | Back Directory | [Boiling point ]
689.8±55.0 °C(Predicted) | [density ]
1.427±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
powder | [pka]
10.74±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Pomalidomide-PEG3-OH (compound 53b) is an E3 Ligase Ligand-Linker Conjugates consisting of a pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker[1]. | [IC 50]
Cereblon | [References]
[1] Zhang X, Thummuri D, Liu X, Hu W, Zhang P, Khan S, Yuan Y, Zhou D, Zheng G. Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity. Eur J Med Chem. 2020 Apr 15;192:112186. DOI:10.1016/j.ejmech.2020.112186 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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