| Identification | Back Directory | [Name]
VH 032-linker 4 | [CAS]
2140807-42-5 | [Synonyms]
VH 032-linker 4
VH 032 amide-PEG3-acid
(S,R. S)-AHPC-PEG3-acid
(S,R,S)-AHPC-PEG3-propionic acid
L-Prolinamide, N-[3-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- | [Molecular Formula]
C32H46N4O9S | [MDL Number]
MFCD32693314 | [MOL File]
2140807-42-5.mol | [Molecular Weight]
662.79 |
| Chemical Properties | Back Directory | [Boiling point ]
930.2±65.0 °C(Predicted) | [density ]
1.264±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO, DMF, MeOH | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
(S, R, S)-AHPC-PEG3-acid is a PROTAC linker that incorporate an E3 ligase ligand with a PEG3 linker to empower PROTAC drug research & discovery. | [Uses]
(S,R,S)-AHPC-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology[1]. | [IC 50]
VHL | [storage]
Store at -20°C | [References]
[1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. DOI:10.1021/acs.jmedchem.6b01912 |
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