| Identification | Back Directory | [Name]
2-[[4-Ethyl-5-(1-methylethyl)-4H-1,2,4-triazol-3-yl]thio]-N-[5-[4-(1-methylethoxy)phenyl]-1,3,4-thiadiazol-2-yl]acetamide | [CAS]
2140901-88-6 | [Synonyms]
2-[[4-Ethyl-5-(1-methylethyl)-4H-1,2,4-triazol-3-yl]thio]-N-[5-[4-(1-methylethoxy)phenyl]-1,3,4-thiadiazol-2-yl]acetamide | [Molecular Formula]
C20H26N6O2S2 | [MOL File]
2140901-88-6.mol | [Molecular Weight]
446.59 |
| Hazard Information | Back Directory | [Uses]
RG100204 is an orally active AQP9 inhibitor with anti-inflammatory activity. RG100204 can alleviate sepsis-induced cardiac dysfunction (both systolic and diastolic), improve renal dysfunction, and reduce the elevation of LDH, a marker of cellular injury[1]. | [References]
[1] Mohammad S, et al. RG100204, a novel Aquaporin-9 inhibitor, reduces septic cardiomyopathy and multiple organ failure in murine sepsis[J]. Frontiers in Immunology, 2022, 13: 900906. DOI:10.3389/fimmu.2022.900906 |
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