| Identification | Back Directory | [Name]
3-BENZYL-7-CHLORO-3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE | [CAS]
21410-06-0 | [Synonyms]
3-benzyl-7-chlorotriazolo[4,5-d]pyrimidine
3-BENZYL-7-CHLORO-3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE
3-benzyl-7-chloro-3h - [1,2,3] thiazol [4,5-d] pyrimidine
3H-1,2,3-Triazolo[4,5-d]pyrimidine, 7-chloro-3-(phenylmethyl)- | [Molecular Formula]
C11H8ClN5 | [MDL Number]
MFCD09038669 | [MOL File]
21410-06-0.mol | [Molecular Weight]
245.67 |
| Chemical Properties | Back Directory | [Boiling point ]
454.9±35.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
0.98±0.30(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-benzyl-7-chloro-3H-[1,2,3]-triazolo[4,5-d]pyrimidines from 3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol: To chloroform (50 mL) containing 3-benzyl-7-hydroxy-3H-[1,2,3]triazolo[4,5-d]pyrimidines (10.56 mmol) suspension, N,N-dimethylformamide (DMF, 2 mL) and thionyl chloride (9 mL) were added sequentially. The reaction mixture was heated to reflux for 3 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure at a temperature below 35 °C. The crude product was purified by silica gel column chromatography with mixed petroleum ether-ethyl acetate solvent as eluent. The final white solid product 3-benzyl-7-chloro-3H-[1,2,3]-triazolo[4,5-d]pyrimidine (1.14 g, 44% yield) was obtained. | [References]
[1] Patent: EP1598354, 2005, A1. Location in patent: Page/Page column 88 |
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| Company Name: |
SynAsst Chemical.
|
| Telephone: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
BePharm Ltd
|
| Telephone: |
400-685-9117 |
| Website: |
www.bepharm.com |
| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
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