| Identification | Back Directory | [Name]
RIPK2-IN-8 | [CAS]
2141969-56-2 | [Synonyms]
RIPK-IN-4
RIPK2-IN-8
2-Pyridinamine, 4-[6-[(1,1-dimethylethyl)sulfonyl]-7-ethoxyimidazo[1,2-a]pyridin-3-yl]-6-fluoro- | [Molecular Formula]
C18H21FN4O3S | [MDL Number]
MFCD32174254 | [MOL File]
2141969-56-2.mol | [Molecular Weight]
392.45 |
| Chemical Properties | Back Directory | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 31.25 mg/mL (79.63 mM) | [form ]
Solid | [pka]
1.59±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
RIPK-IN-4 is a potent and selective RIPK2 inhibitor with excellent oral bioavailability, and has an IC50 of 3 nM[1]. | [References]
[1] He X, et al. Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases. ACS Med Chem Lett. 2017 Sep 27;8(10):1048-1053. DOI:10.1021/acsmedchemlett.7b00258 |
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