| Identification | Back Directory | [Name]
- | [CAS]
2141976-33-0 | [Synonyms]
endo-BCN-PEG3-mal
BCN-PEG3-MAL (ENDO)
BCN-endo-PEG3-Maleimide
Endo-bcn-peg3-maleimide
endo-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (15-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-13-oxo-3,6,9-trioxa-12-azapentadecyl)carbamate
[(1R,8S)-bicyclo[6.1.0]non-4-yn-9-yl]methyl N-{2-[2-(2-{2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy}ethoxy)ethoxy]ethyl}carbamate
5,8,11-Trioxa-2,14-diazaheptadecanoic acid, 17-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-15-oxo-, (1R,8S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester, rel- | [Molecular Formula]
C26H37N3O8 | [MDL Number]
MFCD31811466 | [MOL File]
2141976-33-0.mol | [Molecular Weight]
519.6 |
| Chemical Properties | Back Directory | [Boiling point ]
734.5±60.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Storage temp. -20°C | [solubility ]
DMSO : 50 mg/mL (96.23 mM; ultrasonic and warming and heat to 60°C) | [form ]
Oil | [pka]
12.05±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
endo-BCN-PEG3-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG3-mal is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 19945035818 |
| Website: |
www.topule.com/ |
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