| Identification | Back Directory | [Name]
TCO4-PEG3-NHS | [CAS]
2141981-88-4 | [Synonyms]
TCO4-PEG3-NHS
5,8,11-Trioxa-2-azatetradecanedioic acid, 1-(4-cycloocten-1-yl) 14-(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C22H34N2O9 | [MDL Number]
MFCD31811534 | [MOL File]
2141981-88-4.mol | [Molecular Weight]
470.51 |
| Hazard Information | Back Directory | [Description]
TCO-PEG3-NHS Ester is a PEG linker containing a TCO moiety and a NHS ester. The hydrophilic PEG spacer increases water-solubility and a decreases steric hindrance during ligation. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. | [Uses]
TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001 |
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