| Identification | Back Directory | [Name]
2BAct(eIF2B activator 2BAct) | [CAS]
2143542-28-1 | [Synonyms]
2BAct
2BAct(eIF2B activator 2BAct)
N-(3-(2-(4-Chloro-3-fluorophenoxy)acetamido)bicyclo[1.1.1]pentan-1-yl)-5-(difluoromethyl)pyrazine-2-carboxamide
2-Pyrazinecarboxamide, N-[3-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]bicyclo[1.1.1]pent-1-yl]-5-(difluoromethyl)-
permeable,primary,inhibit,Eukaryotic Initiation Factor (eIF),2BAct,stress,defects,response,fibroblast,neurological,Inhibitor,CNS | [Molecular Formula]
C19H16ClF3N4O3 | [MDL Number]
MFCD34567268 | [MOL File]
2143542-28-1.mol | [Molecular Weight]
440.8 |
| Chemical Properties | Back Directory | [Boiling point ]
671.6±55.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
12.16±0.40(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Uses]
2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495)[1]. | [in vivo]
2BAct (300 μg 2BAct/g of meal; 21 weeks) normalizes body weight gain in VWM mice[1].
2BAct prevents the appearance of motor deficits, myelin loss and reactive gliosis in VWM mice[1].
2BAct stimulates the remaining activity of mutant eIF2B complex in vivo, abrogating the maladaptive stress response[1]. | [IC 50]
eIF2 | [References]
[1] Wong YL, et al. eIF2B activator prevents neurological defects caused by a chronic integrated stress response. Elife. 2019;8:e42940. Published 2019 Jan 9. DOI:10.7554/eLife.42940 |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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