ChemicalBook--->CAS DataBase List--->2143896-83-5

2143896-83-5

Request For Quotation
2143896-83-5 Structure

2143896-83-5 Structure
IdentificationBack Directory
[Name]

PKUMDL-LC-101-D04
[CAS]

2143896-83-5
[Synonyms]

PKUMDL-LC-101-D04
GPX4-Activator-1d4
PKUMDL LC 101 D04,PKUMDL-LC-101-D-04,PKUMDLLC101D04
[Molecular Formula]

C14H23ClN4O2S2
[MOL File]

2143896-83-5.mol
[Molecular Weight]

378.93
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: soluble
[form ]

A crystalline solid
[color ]

White to off-white
[Water Solubility ]

H2O: 2mg/mL, clear
Hazard InformationBack Directory
[Description]

PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4).1 It increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay and at 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts. PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death.
[Uses]

PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation[1][2].
[storage]

Store at -20°C
[References]

1. Li, C., Deng, X., Zhang, W., et al. Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4 J. Med. Chem. 62(1),266-275(2019).
Spectrum DetailBack Directory
[Spectrum Detail]

PKUMDL-LC-101-D04(2143896-83-5)1HNMR
2143896-83-5 suppliers list
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Telephone: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Telephone: 15026964105
Website: www.shyuanye.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Telephone: QQ：65489617 13301690235
Website: www.atkchemical.com/
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Telephone: 400-9205774 400-920-5774
Website: www.glpbio.cn
Company Name: Wuxi Donghe Pharmaceutical Technology Co., Ltd.  
Telephone: 63313187 15358055255
Website: http://www.cegchemical.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Telephone: 18818260767
Website: http://www.chemegen.com
Company Name: ShangHai ChuanQian Chemcial Technique Centre  
Telephone: 15869524721
Website: www.chemicalbook.com/ShowSupplierProductsList68594/0_EN.htm
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Telephone: 010-60605840
Website: http://www.jm-bio.com/
Company Name: Shanghai Universal Biotech Co.,Ltd  
Telephone: 15921930842 15921930842
Website: www.univ-bio.com/
Company Name: Bide Pharmatech Ltd.  
Telephone: 400-1647117 13681763483
Website: https://www.bidepharm.com/
Company Name: TargetMol Chemicals Inc.  
Telephone: 4008200310 15002144251
Website: https://www.targetmol.cn/
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd  
Telephone: 024-88590548 18698872706
Website:
Company Name: Wuhan Jingkangen Biomedical Technology Co., Ltd  
Telephone: 13720134139 086-15871494362 13720134139
Website: https://www.jknbiochem.com
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Telephone: 0513-66337626 18051384581
Website: https://www.chemhifuture.com/
Company Name: RD International Technology Co., Limited  
Telephone: 18024082417
Website: www.ruidiresearch.com
Company Name: Chengdu Peter-like Biotechnology Co., Ltd.  
Telephone: 028-81700200 13308200041
Website: www.weikeqi-biotech.com/
Company Name: Henan Yinuokai New Materials Co., Ltd  
Telephone: 18836288690 18836288690
Website:
Company Name: Shaanxi Didu Pharmaceutical Co., Ltd.  
Telephone: 029-81124775 17791530730
Website:
Tags:2143896-83-5 Related Product Information
89889-52-1 41931-13-9 109276-34-8 3040858-60-1 191671-46-2 1035072-16-2