| Identification | Back Directory | [Name]
N3-PEG5-CH2CO2-NHS | [CAS]
2144777-77-3 | [Synonyms]
N3-PEG5-CH2COONHS
N3-PEG5-CH2CO2-NHS
AZIDO-PEG5-CH2CO2-NHS
Azido-PEG5-CH2COOH NHS Ester | [Molecular Formula]
C16H26N4O9 | [MDL Number]
MFCD31561145 | [MOL File]
2144777-77-3.mol | [Molecular Weight]
418.4 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, sealed storage, away from moisture | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Azido-PEG5-CH2CO2-NHS is a very active pegylation reagent with 5 PEG units. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group allows the reaction with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
Azido-PEG5-CH2CO2-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG5-CH2CO2-NHS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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