| Identification | Back Directory | [Name]
6,8-DIFLUORO-4-METHYL-UMBELLIFERYL PHOSPHATE | [CAS]
214491-43-7 | [Synonyms]
DIFMUP
AURORA KA-6718
6,8-DIFLUORO-4-METHYL-UMBELLIFERYL PHOSPHATE
2H-1-Benzopyran-2-one, 6,8-difluoro-4-methyl-7-(phosphonooxy)- | [Molecular Formula]
C10H7F2O6P | [MDL Number]
MFCD01863005 | [MOL File]
214491-43-7.mol | [Molecular Weight]
292.13 |
| Chemical Properties | Back Directory | [Boiling point ]
496.0±55.0 °C(Predicted) | [density ]
1.716±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
29.21mg/ml in DMSO | [form ]
A solid | [pka]
1.48±0.10(Predicted) | [color ]
White to off-white | [Appearance]
Solid Powder | [InChI]
1S/C10H7F2O6P/c1-4-2-7(13)17-9-5(4)3-6(11)10(8(9)12)18-19(14,15)16/h2-3H,1H3,(H2,14,15,16) | [InChIKey]
DZANYXOTJVLAEE-UHFFFAOYSA-N | [SMILES]
CC1=CC(=O)Oc2c(F)c(OP(O)(O)=O)c(F)cc12 |
| Hazard Information | Back Directory | [Description]
6,8-difluoro-4-methylumbelliferyl phosphate is a fluorogenic substrate for protein tyrosine phosphatase. | [Uses]
DiFMUP is a fluorogenic substrate, and has been widely used for the continuous detection of phosphatase activities. DiFMUP is hydrolysis by a phosphatase results in the release of Xuorescent DIFMU, which can be easily followed in continuous mode by a Xuorescence reader[1][2]. | [Definition]
ChEBI: 6,8-difluoro-4-methylumbelliferyl phosphate is a member of coumarins. It is functionally related to a coumarin. It is a conjugate acid of a 6,8-difluoro-4-methylumbelliferyl phosphate (2-). | [Biological Activity]
DiFMUP (6,8-difluoro-4-methylumbelliferyl phosphate)a fluorinated analog of MUPis a fluorescent synthetic substrate for continuous assessment of phosphatase activity. DiFMUP excitation/emission maxima are 358/450 nm. | [storage]
Store at -20°C | [References]
[1] Gee KR, et, al. Fluorogenic substrates based on fluorinated umbelliferones for continuous assays of phosphatases and beta-galactosidases. Anal Biochem. 1999 Aug 15;273(1):41-8. DOI:10.1006/abio.1999.4202
[2] Welte S, et, al. 6,8-Difluoro-4-methylumbiliferyl phosphate: a fluorogenic substrate for protein tyrosine phosphatases. Anal Biochem. 2005 Mar 1;338(1):32-8. DOI:10.1016/j.ab.2004.11.047 |
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