| Identification | Back Directory | [Name]
5-Hydroxy-2-phenyl-7-(phenylmethoxy)-8-[4-(1-pyrrolidinyl)butoxy]-4H-1-benzopyran-4-one | [CAS]
2146090-18-6 | [Synonyms]
5-Hydroxy-2-phenyl-7-(phenylmethoxy)-8-[4-(1-pyrrolidinyl)butoxy]-4H-1-benzopyran-4-one | [Molecular Formula]
C30H31NO5 | [MOL File]
2146090-18-6.mol | [Molecular Weight]
485.57 |
| Chemical Properties | Back Directory | [Melting point ]
132-134 °C | [Boiling point ]
689.2±55.0 °C(Predicted) | [density ]
1.239±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
6.71±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
LW-216 is a TrxR1 inhibitor that induces Apoptosis. LW-216 has anti-tumor activity[1]. | [in vivo]
LW-216 (8 mg/kg, intravenously, once every two days for 18 days) inhibits tumor growth of NCI-H460 cells in a xenograft mouse model[1].
| Animal Model: | NCI-H460 cells in a xenograft mice model[1] | | Dosage: | 8 mg/kg, once every two days for 18 days | | Administration: | i.v. | | Result: | Reduced bioluminescence intensity.
Increased the expression of apoptosis-related proteins Bax and Cleaved Caspase-3, while decreasing the expression of the proliferation-related protein Ki67.
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| [References]
[1] Wang R, et al. Inducing ubiquitination and degradation of TrxR1 protein by LW-216 promotes apoptosis in non-small cell lung cancer via triggering ROS production. Neoplasia. 2024 Jul;53:101004 DOI:10.1016/j.neo.2024.101004 |
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