| Identification | Back Directory | [Name]
L-Leucine, N'-[[3-(1,1-dimethylethyl)-1-methyl-1H-pyrazol-5-yl]carbonyl]-, 2-cyano-1,2-dimethylhydrazide | [CAS]
2151025-98-6 | [Synonyms]
LmCPB-IN-1
L-Leucine, N'-[[3-(1,1-dimethylethyl)-1-methyl-1H-pyrazol-5-yl]carbonyl]-, 2-cyano-1,2-dimethylhydrazide | [Molecular Formula]
C18H30N6O2 | [MOL File]
2151025-98-6.mol | [Molecular Weight]
362.48 |
| Hazard Information | Back Directory | [Uses]
LmCPB-IN-1 (compound 35) is a potent and reversible covalent Leishmania mexicana cysteine protease B (LmCPB) inhibitor with a pKi of 9.7[1]. | [References]
[1] Jean F R Ribeiro, et al. Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor. Bioorg Med Chem. 2020 Nov 15;28(22):115743. DOI:10.1016/j.bmc.2020.115743 |
|
|