| Identification | Back Directory | [Name]
5,5'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))bis(2-hydroxybenzoic acid) | [CAS]
215294-98-7 | [Synonyms]
X-34
X-34 >=90% (HPLC)
Benzoic acid, 3,3'-(1,4-phenylenedi-2,1-ethenediyl)bis[6-hydroxy-
5,5'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))bis(2-hydroxybenzoic acid) | [Molecular Formula]
C24H18O6 | [MOL File]
215294-98-7.mol | [Molecular Weight]
402.4 |
| Chemical Properties | Back Directory | [Boiling point ]
669.9±55.0 °C(Predicted) | [density ]
1.448±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2.0mg/mL, clear | [form ]
Solid | [pka]
2.85±0.10(Predicted) | [color ]
Light yellow to yellow | [InChI]
1S/C24H18O6/c25-21-11-9-17(13-19(21)23(27)28)7-5-15-1-2-16(4-3-15)6-8-18-10-12-22(26)20(14-18)24(29)30/h1-14,25-26H,(H,27,28)(H,29,30) | [InChIKey]
MCBNOAYTZBUCSX-UHFFFAOYSA-N | [SMILES]
OC(C=C1)=C(C(O)=O)C=C1C=CC2=CC=C(C=CC3=CC=C(O)C(C(O)=O)=C3)C=C2 |
| Hazard Information | Back Directory | [Uses]
X-34 is a lipophilic and bright yellow-green fluorescent derivative of Congo red (HY-D0236). X-34 can be used to stain neuritic and diffuse plaques, neurofibrillary tangles (NFTs), neuropil threads, and cerebrovascular amyloid in the brain. X-34 can be used for research of Alzheimer’s disease[1]. | [Biological Activity]
Fluorescentamyloid-specific dye''X-34 (1,4-bis(3-carboxy-4-hydroxyphenylethenyl)-benzene) is one among the small-molecule γ-secretase modulators (GSMs) involved in lowering Aβ42 levels (the 42-residue isoform of the amyloid-β peptide). X-34 has also been used to visualize intracellular immunoreactive deposits with classic amyloid fibrillar ultrastructure in living transgenic Caenorhabditis elegans animals. It is also used as a histochemical stain for determining pathological changes in Alzheimerμs disease (AD).''X-34 is a fluorescentamyloid-specific dye. It binds at a different site than Pittsburgh Compound B and is a highly fluorescent marker for beta-sheet structures. | [References]
[1] Styren SD, et al. X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology. J Histochem Cytochem. 2000 Sep;48(9):1223-32. DOI:10.1177/002215540004800906
[2] Link CD, et al. Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol Aging. 2001 Mar-Apr;22(2):217-26. DOI:10.1016/s0197-4580(00)00237-2 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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