| Identification | Back Directory | [Name]
ROS tracer precursor | [CAS]
2153480-20-5 | [Synonyms]
ROS tracer precursor
Carbamic acid, N-[8-[[(1,1-dimethylethoxy)carbonyl]amino]-5,6-dihydro-5-methyl-6-[4-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]phenyl]-3-phenanthridinyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C39H45N3O8S | [MDL Number]
MFCD32263398 | [MOL File]
2153480-20-5.mol | [Molecular Weight]
715.85 |
| Chemical Properties | Back Directory | [Boiling point ]
784.6±60.0 °C(Predicted) | [density ]
1.258±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.50±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ROS tracer precursor is the precursor of [18F]ROStrace for the synthesis of ROStrace, which can be used for disease diagnosis[1]. | [in vivo]
[18F]ROStrace is a radiotracer for imaging superoxide in vivo with positron emission tomography (PET), in an LPS model of neuroinflammation. [18F]ROStrace is found to rapidly cross the blood-brain barrier (BBB) and is trapped in the brain of LPS-treated animals. [18F]ox-ROStrace, the oxidized form of [18F]ROStrace, does not cross the BBB. [18F]ROStrace is a suitable radiotracer for imaging superoxide levels in the central nervous system with PET[1]. | [References]
[1] Hou C, et al. Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation. ACS Chem Neurosci. 2018 Mar 21;9(3):578-586. DOI:10.1021/acschemneuro.7b00385 |
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