| Chemical Properties | Back Directory | [Melting point ]
129-130 °C | [Boiling point ]
842.3±65.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
11.54±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC50 of 45 nM[1]. | [References]
[1] Tanaka A, et al. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas with weak toxicological effects on adrenal glands. J Med Chem. 1998 Oct 22;41(22):4408-20. DOI:10.1021/jm980399q |
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