| Identification | Back Directory | [Name]
15-KETO PROSTAGLANDIN F1ALPHA | [CAS]
21562-58-3 | [Synonyms]
15-keto Prostaglandin F1α
15-KETO PROSTAGLANDIN F1ALPHA
15-keto Prostaglandin F1α MaxSpec? Standard
9ALPHA,11ALPHA-DIHYDROXY-15-OXO-PROST-13E-EN-1-OIC ACID
Prost-13-en-1-oic acid, 9,11-dihydroxy-15-oxo-, (9α,11α,13E)- | [Molecular Formula]
C20H34O5 | [MDL Number]
MFCD00135228 | [MOL File]
21562-58-3.mol | [Molecular Weight]
354.48 |
| Hazard Information | Back Directory | [Description]
15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins. | [Uses]
15-keto Prostaglandin F1α (15-keto PGF1α) is a prostaglandin F1α metabolite. 15-keto Prostaglandin F1α (15-keto PGF1α) is an effective substrate for PGR-2. 15-keto Prostaglandin F1α (15-keto PGF1α) can be used to study physiological processes such as prostaglandin metabolism and lipogenesis[1]. | [References]
[1] Chou WL, et al. Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. J Biol Chem. 2007 Jun 22;282(25):18162-18172. DOI:10.1074/jbc.M702289200 |
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