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2157482-40-9

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2157482-40-9 Structure

2157482-40-9 Structure

Identification	Back Directory
[Name] FGFR1 inhibitor-11
[CAS] 2157482-40-9
[Synonyms] FGFR1 inhibitor-11
[Molecular Formula] C23H18O4
[MOL File] 2157482-40-9.mol
[Molecular Weight] 358.39

Chemical Properties	Back Directory
[Boiling point ] 550.5±50.0 °C(predicted)
[density ] 1.289±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 9.95±0.30(predicted)

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[Uses] FGFR1 inhibitor-11 (compound 5g) binds to FGFR1, inactivation of its downstream ERK1/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR1 inhibitor-11 has oral bioactivity[1].
[in vivo] FGFR1 inhibitor-11 (15-30 mg/kg; p.o.; 2 times per day) significantly preventes bone loss (BV, T-BMD, etc.) in mice^[1].
[References] [1] Zhihao Chen, et al. Discovery of a novel homoisoflavonoid derivative 5g for anti-osteoclastic bone loss via targeting FGFR1. Eur J Med Chem. 2024 Mar 27:270:116335. DOI:10.1016/j.ejmech.2024.116335

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Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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