| Identification | Back Directory | [Name]
5-Nitro-N-(3-pyridinylmethyl)-2-furancarboxamide | [CAS]
215778-97-5 | [Synonyms]
CCCI-01
CCCI-01 >=98% (HPLC)
5-nitro-N-(3-pyridinylmethyl)-2-furamide
Centrosome Clustering Chemical Inhibitor-01
5-Nitro-N-(3-pyridinylmethyl)-2-furancarboxamide
5-Nitro-N-(pyridin-3-ylmethyl)furan-2-carboxamide
2-Furancarboxamide, 5-nitro-N-(3-pyridinylmethyl)- | [Molecular Formula]
C11H9N3O4 | [MDL Number]
MFCD00218071 | [MOL File]
215778-97-5.mol | [Molecular Weight]
247.21 |
| Hazard Information | Back Directory | [Uses]
CCCI-01 is a centrosome clustering inhibitor. CCCI-01 has selective effects on cancer. CCCI-01 can be used for the research of non-cross-resistant anti-cancer agents with blocking centrosome clustering[1]. | [Biological Activity]
CCCI-01 induces the fomation of multipolar spindles in cancer cells containing multipleor supernumerary centromeres. CCCI-01 leads to centromere declusteringdisruption of cell cycle and apoptsis in BT-549 breast cancer cells without affecting bipolar spindles in normal primary human mammary epithelial cells. | [References]
[1] Kawamura E, et al. Identification of novel small molecule inhibitors of centrosome clustering in cancer cells. Oncotarget. 2013 Oct;4(10):1763-76. DOI:10.18632/oncotarget.1198 |
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Energy Chemical
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Merck KGaA
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Specs
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