| Identification | Back Directory | [Name]
SB 277011 Hydrochloride | [CAS]
215804-67-4 | [Synonyms]
SB 277011 Hydrochloride
SB 277211 Hydrochloride
SB 277011A Hydrochloride
SB-277011-A hydrochloride hydrate
N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-
4-quinolinecarboxaMide Hydrochloride | [Molecular Formula]
C28H30N4O | [MDL Number]
MFCD16875431 | [MOL File]
215804-67-4.mol | [Molecular Weight]
438.564 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble2mg/mL, clear (warmed) | [form ]
powder | [color ]
white to beige | [Water Solubility ]
Water: 16.67 mg/mL (35.09 mM) | [InChIKey]
OOWNBQACGIKNGM-ONAIBGCWSA-N | [SMILES]
O.Cl.O=C(N[C@@H]1CC[C@H](CC1)CCN2CCc3cc(ccc3C2)C#N)c4ccnc5ccccc45 |
| Hazard Information | Back Directory | [Uses]
A potent and selective dopamine D3 receptor antagonist. | [Biochem/physiol Actions]
The D3 dopamine receptor antagonist, SB-277011-A inhibits the cocaine-seeking behavior and cocaine-enhances brain stimulation reward in in rats. It decreases drug-seeking behavior and may be useful in treatment of cocaine and methamphetamine addiction. |
|
| Company Name: |
Sigma-Aldrich
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Alfa Chemistry
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Energy Chemical
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http://www.energy-chemical.com |
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Merck KGaA
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www.sigmaaldrich.cn |
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