ChemicalBook--->CAS DataBase List--->21586-90-3

21586-90-3

21586-90-3 Structure

21586-90-3 Structure
IdentificationBack Directory
[Name]

bruceine E
[CAS]

21586-90-3
[Synonyms]

Brucein E
20-Deoxybruceine F
2-O-Demethylbruceine M
13,20-Epoxy-1β,2α,11β,12α,14,15β-hexahydroxypicras-3-en-16-one
Picras-3-en-16-one, 13,20-epoxy-1,2,11,12,14,15-hexahydroxy-, (1β,2α,11β,12α,15β)-
[Molecular Formula]

C20H28O9
[MDL Number]

MFCD00221754
[MOL File]

21586-90-3.mol
[Molecular Weight]

412.43
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Bruceine E is a quassinoid from seeds of Brucea javanica (L.) Merr, exhibiting hypoglycemia effect[1]. Bruceine E exhibits blood glucose lowering effect in both nondiabetic mice and Streptozotocin (STZ (HY-13753))-induced diabetic rats at lower dose[2].
[in vivo]

Bruceine D and E, isolated from B. javanica seeds, exhibits blood glucose lowering effect in both nondiabetic mice and STZ-induced diabetic rats at lower dose (1 mg/kg b.w.) during 0-8 h screening[2].

[References]

[1] Man F, et al. HPLC-MS/MS method for bioavailability study of bruceines D & E in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 15;1063:183-188. DOI:10.1016/j.jchromb.2017.08.037
[2] Ablat A, et al. Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats. BMC Complement Altern Med. 2017;17(1):94. Published 2017 Feb 6. DOI:10.1186/s12906-017-1610-x
Spectrum DetailBack Directory
[Spectrum Detail]

bruceine E(21586-90-3)1HNMR
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