| Identification | Back Directory | [Name]
1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-6-(4-methyl-1-piperazinyl)-N-[4-(4-pyridinyl)-1-naphthalenyl]- | [CAS]
216058-27-4 | [Synonyms]
SB272183
SB-272183
SB 272183
1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-6-(4-methyl-1-piperazinyl)-N-[4-(4-pyridinyl)-1-naphthalenyl]- | [Molecular Formula]
C29H28ClN5O | [MOL File]
216058-27-4.mol | [Molecular Weight]
498.02 |
| Hazard Information | Back Directory | [Description]
SB 272183 is a highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drug. | [Uses]
SB-272183 is a selective 5-HT1A, 5-HT1B and 5-HT1D receptor antagonist. In addition, SB-272183 is also a potent and selective ligand for 5-HT1A, 5-HT1B and 5-HT1D receptors in human recombinant and native tissues with pKi values of 8.0, 8.1 and 8.7, respectively. SB-272183 can be used in antidepressant research[1]. | [IC 50]
5-HT1A Receptor: 8.0 (pKi); 5-HT1B Receptor: 8.1 (pKi); 5-HT1D Receptor: 8.7 (pKi) | [References]
[1] Watson J, et al. SB‐272183, a selective 5‐HT1A, 5‐HT1B and 5‐HT1D receptor antagonist in native tissue[J]. British journal of pharmacology, 2001, 133(6): 797-806. DOI:10.1038/sj.bjp.0704133 |
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