| Identification | Back Directory | [Name]
Triapine hydrochloride | [CAS]
216240-62-9 | [Synonyms]
Triapine hydrochloride
Hydrazinecarbothioamide, 2-[(3-amino-2-pyridinyl)methylene]-, hydrochloride (1:1) | [Molecular Formula]
C7H9N5S.ClH | [MOL File]
216240-62-9.mol | [Molecular Weight]
231.71 |
| Hazard Information | Back Directory | [Uses]
Triapine (hydrochloride) is the hydrochloride form of Triapine (HY-10082). Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer[1]. | [References]
[1] Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e475-81. DOI:10.1016/j.ijrobp.2012.06.003 |
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