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2162952-37-4

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2162952-37-4 Structure

2162952-37-4 Structure

Identification	Back Directory
[Name] PMMB-187
[CAS] 2162952-37-4
[Synonyms] PMMB-187 Acetic acid, 2-[[5-[(4-bromophenyl)methyl]-1,3,4-thiadiazol-2-yl]thio]-, (1R)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxo-2-naphthalenyl)-4-methyl-3-penten-1-yl ester
[Molecular Formula] C27H23BrN2O6S2
[MOL File] 2162952-37-4.mol
[Molecular Weight] 615.52

Chemical Properties	Back Directory
[Boiling point ] 816.1±75.0 °C(predicted)
[density ] 1.61±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 7.04±0.20(predicted)

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[Uses] PMMB-187 is a selective STAT3 inhibitor with an IC50 value of 1.81 μM for MDA-MB-231 cells. PMMB-187 induces apoptosis (Apoptosis) in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity, nuclear translocation, and downstream target gene expression, while also reducing mitochondrial membrane potential, generating reactive oxygen species (ROS), and upregulating the expression levels of apoptosis-related proteins. PMMB-187 has potential applications in cancer research[1].
[IC 50] Stat-3: 1.81 μM (IC₅₀)
[References] [1] Qiu HY, et al. Identification of new shikonin derivatives as STAT3 inhibitors. Biochem Pharmacol. 2017 Dec 15;146:74-86. DOI:10.1016/j.bcp.2017.10.009

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