| Identification | Back Directory | [Name]
Guanoxan | [CAS]
2165-19-7 | [Synonyms]
Guanoxan
Guanoxane
Guanoxan USP/EP/BP
2-(GuanidinoMethyl)-1,4-benzodioxan
(1,4-Benzodioxan-2-ylmethyl)guanidine
1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)guanidine
2-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)guanidine
N-[(2,3-Dihydro-1,4-benzodioxin-2-yl)Methyl]guanidine
Guanidine, N-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]- | [Molecular Formula]
C10H13N3O2 | [MOL File]
2165-19-7.mol | [Molecular Weight]
207.23 |
| Hazard Information | Back Directory | [Chemical Properties]
Guanidine sulfate (5714-04-5) is a white crystalline powder with a melting point of 205-208°C. It is soluble in water and has an odorless, bitter taste. | [Originator]
Envacar,Pfizer | [Uses]
Guanoxan is a sympatholytic drug related to Guanethidine (G815000). Guanoxan is used in the treatment of hypertension. | [Definition]
ChEBI: Guanoxan is a benzodioxine. | [Manufacturing Process]
2 Methods of producing of 2-guanidinemethyl-2,3-dihydro-1,4-benzodioxine:
1. 3.3 parts by weight of 2-aminomethyl-1,4-benzodioxane and 2.78 parts by
weight of S-methylisothiouronium sulfate were dissolved in 20 parts by
volume of water, and the resulting aqueous solution was heated under reflux
for 3 h. At the end of this time, the solvent was removed by means of
evaporation under reduced pressure and the residue so obtained dissolved in
a minimum amount of fresh water and treated with charcoal. Upon filtration,
there was obtained a clear filtrate which, on standing, soon afforded pure
crystals of di(2-guanidinomethyl-1,4-benzodioxane)sulfate, melting point
204°-205°C.
The base 2-guanidinemethyl-2,3-dihydro-1,4-benzodioxine may be obtained
by reaction of di(2-guanidinomethyl-1,4-benzodioxane)sulfate with, for
example, sodium hydroxide.
2. o-Dihydroxybenzene reacted with epichlorhydrine in the presence sodium
hydroxide and 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine was obtained.
To solution of 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine thionylchloride
was added to give 2-chlormethyl-2,3-dihydro-1,4-benzodioxine.
2-Chloromethyl-2,3-dihydro-1,4-benzodioxine reacted with benzylamine to
produced 2-benzylaminomethyl-2,3-dihydro-1,4-benzodioxine, which was
reduced at the presence of hydrogen and Pd-C (catalyst) to 2-aminomethyl-
2,3-dihydro-1,4-benzodioxine.
2-Aminomethyl-2,3-dihydro-1,4-benzodioxine was treated by Smethylisothiouronium sulfate and there was produced 2-guanidinemethyl-2,3-
dihydro-1,4-benzodioxine. | [Brand name]
Envacar (Pfizer). | [Therapeutic Function]
Antihypertensive |
|
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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Pharma Affiliates
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172-5066494 |
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www.chemicalbook.com/ShowSupplierProductsList694812/0_EN.htm |
| Company Name: |
Leancare Ltd.
|
| Tel: |
+33 962096793 |
| Website: |
www.leancare.co.uk |
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