| Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxamide, N-[(3-fluoro-4-methoxy-2-pyridinyl)methyl]-1-[[4-[(5-fluoro-2-oxo-1(2H)-pyridinyl)methyl]phenyl]methyl]-3-(methoxymethyl)- | [CAS]
2166320-76-7 | [Synonyms]
Feniralstat
1H-Pyrazole-4-carboxamide, N-[(3-fluoro-4-methoxy-2-pyridinyl)methyl]-1-[[4-[(5-fluoro-2-oxo-1(2H)-pyridinyl)methyl]phenyl]methyl]-3-(methoxymethyl)- | [Molecular Formula]
C26H25F2N5O4 | [MOL File]
2166320-76-7.mol | [Molecular Weight]
509.5 |
| Chemical Properties | Back Directory | [Boiling point ]
732.4±60.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
12.49±0.46(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC50 of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC50>40 μM). | [References]
[1] Rebecca Louise DAVIE, et al. Pyrazole derivatives as plasma kallikrein inhibitors. WO2017207983A1. |
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