| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2166487-23-4 | [Synonyms]
Et-29
NRD167
Z-Lys（thiourea-beta-Ala-OEt）-Trp-Isopropylamine
ethyl (5S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate | [Molecular Formula]
C34H46N6O6S | [MDL Number]
MFCD34593624 | [MOL File]
2166487-23-4.mol | [Molecular Weight]
666.84 |
| Chemical Properties | Back Directory | [density ]
1.225±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
11.08±0.46(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
Et-29 is a potent and selective SIRT5 inhibitor (Ki=40 nM)[1]. | [Biological Activity]
Et-29 is a potent and selective SIRT5 inhibitor (Ki=40 nM)[1]. | [IC 50]
SIRT5: 40 nM (Ki) | [References]
[1]. Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017;56(47):14836-14841. |
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