| Identification | Back Directory | [Name]
7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one | [CAS]
216691-95-1 | [Synonyms]
BZ48
Bz-423
Bz-423 >=98% (HPLC)
7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one
7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-Methyl-3-(2-naphthalenylMethyl)- | [Molecular Formula]
C27H21ClN2O2 | [MOL File]
216691-95-1.mol | [Molecular Weight]
440.92 |
| Chemical Properties | Back Directory | [Boiling point ]
697.2±55.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 125 mg/mL (283.50 mM) | [form ]
Solid | [pka]
9.05±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Bz-?423 is a 1,?4-?benzodiazepine that suppresses disease in lupus-?prone mice by selectively killing pathogenic lymphocytes. | [Biological Activity]
Bz-423 is an inhibitor of mitochondrial F1F0 ATP synthase. It binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPaseresulting in superoxide generation and apoptosis. BZ-423 was shown to block multidrug-resistant melanoma cells. In another studyBz-423 selectively increased superoxide and induced the apoptosis of alloreactive T cellswhich arrested established Graft versus Host Disease.''Bz-423 stimulates mitochondrial inner membrane pore (MIMP) opening in isolated mitochondria. | [IC 50]
Bax; Bak | [storage]
Store at -20°C |
|
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Telephone: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
|