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216699-07-9

216699-07-9 Structure

216699-07-9 Structure
IdentificationBack Directory
[Name]

Abacavir (sulfate)
[CAS]

216699-07-9
[Synonyms]

Abacavir monosulfate
[Molecular Formula]

C14H20N6O5S
[MOL File]

216699-07-9.mol
[Molecular Weight]

384.41
Chemical PropertiesBack Directory
[solubility ]

DMSO: 0.15 mg/ml; PBS (pH 7.2): 1 mg/ml
[form ]

A crystalline solid
Safety DataBack Directory
[Symbol(GHS) ]


GHS07,GHS08
[Signal word ]

Warning
[Hazard statements ]

H319-H317-H341-H351-H361
[Precautionary statements ]

P201-P202-P261-P264-P272-P280-P302+P352-P305+P351+P338-P308+P313-P321-P333+P313-P337+P313-P363-P405-P501
Hazard InformationBack Directory
[Uses]

Abacavir (sulfate) is an antiviral analog of guanosine, inhibiting the reverse transcriptase of HIV type 1 with an IC50 value of 5.3 μM. This blocks retroviral replication, which assists in retroviral therapy. Abacavir (sulfate), commonly used in combination with other antiretroviral compounds, has been associated with a diagnosis of hypersensitivity syndrome.[Cayman Chemical]
[in vivo]

Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) monosulfate dose-dependently promoted thrombus formation[2].
Abacavir (50 mg/kg/d; i.p.; 14 days) monosulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3].

Animal Model:Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)[2]
Dosage:2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg
Administration:Intrascrotal or oral administration for 4 h
Result:Dose-dependently promoted thrombus formation.
Animal Model:NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma[3]
Dosage:50 mg/kg/d with 0.1 mg/kg/d Decitabine
Administration:Intraperitoneal injection, daily for 14 days
Result:Inhibited tumor growth and enhanced mouse survival.
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Company Name: Cayman Chemical Company  
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