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Abacavir (sulfate) is an antiviral analog of guanosine, inhibiting the reverse transcriptase of HIV type 1 with an IC50 value of 5.3 μM. This blocks retroviral replication, which assists in retroviral therapy. Abacavir (sulfate), commonly used in combination with other antiretroviral compounds, has been associated with a diagnosis of hypersensitivity syndrome.[Cayman Chemical]
| [in vivo]
Abacavir (0-7.5 μg/mL, 100 μL, intrascrotal administration; 100 and 200 mg/kg, p.o.; 4 h) monosulfate dose-dependently promoted thrombus formation[2].
Abacavir (50 mg/kg/d; i.p.; 14 days) monosulfate with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3]. Animal Model: | Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)[2] | Dosage: | 2.5, 5 and 7.5 μg/mL, 100 μL or 100 and 200 mg/kg | Administration: | Intrascrotal or oral administration for 4 h | Result: | Dose-dependently promoted thrombus formation. |
Animal Model: | NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma[3] | Dosage: | 50 mg/kg/d with 0.1 mg/kg/d Decitabine | Administration: | Intraperitoneal injection, daily for 14 days | Result: | Inhibited tumor growth and enhanced mouse survival. |
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BOC Sciences
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Company Name: |
BOC Sciences
|
Tel: |
16314854226 |
Website: |
www.bocsci.com |
|