| Identification | Back Directory | [Name]
5,6,7,8-TETRAHYDRO-6-METHYL-1,6-NAPHTHYRIDIN-3-AMINE | [CAS]
216966-37-9 | [Synonyms]
6-methyl-7,8-dihydro-5H-1,6-naphthyridin-3-amine
5,6,7,8-TETRAHYDRO-6-METHYL-1,6-NAPHTHYRIDIN-3-AMINE
6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-3-amine
3-Amino-5,6,7,8-tetrahydro-6-methyl-1,6-naphthyridine
1,6-Naphthyridin-3-amine, 5,6,7,8-tetrahydro-6-methyl- | [Molecular Formula]
C9H13N3 | [MDL Number]
MFCD09743968 | [MOL File]
216966-37-9.mol | [Molecular Weight]
163.22 |
| Chemical Properties | Back Directory | [Boiling point ]
324.1±42.0 °C(Predicted) | [density ]
1.142±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
7.12±0.20(Predicted) | [Appearance]
White to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-amino-5,6,7,8-tetrahydro-6-methyl-1,6-naphthyridine from 6-methyl-3-nitro-5,6,7,8-tetrahydro-6-methyl-1,6-naphthyridine: To a mixture of ethanol (35 mL) and 2-methyltetrahydrofuran (35 mL) of intermediate 128 (1.50 g, 7.76 mmol) was added palladium/carbon catalyst ( 10 wt.%) (826.24 mg, 0.77 mmol) and the reaction mixture was stirred under hydrogen atmosphere for 2 hours. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filter cake was washed with ethanol. The filtrate was concentrated under reduced pressure to give 1.33 g of Intermediate 129, which crystallized on standing (quantitative yield, 95% purity based on 1H NMR analysis, yellow oily). | [References]
[1] Patent: WO2018/2219, 2018, A1. Location in patent: Page/Page column 290; 291
[2] Synthetic Communications, 2001, vol. 31, # 5, p. 787 - 797 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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