| Identification | Back Directory | [Name]
Acetamide, 2-[[[4-(1,2-dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenyl]methyl]methylamino]-N-[8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]octyl]- | [CAS]
2170679-42-0 | [Synonyms]
dBRD9-A
Acetamide, 2-[[[4-(1,2-dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenyl]methyl]methylamino]-N-[8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]octyl]- | [Molecular Formula]
C42H49N7O8 | [MOL File]
2170679-42-0.mol | [Molecular Weight]
779.9 |
| Chemical Properties | Back Directory | [Boiling point ]
999.6±65.0 °C(Predicted) | [density ]
1.304±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO|77.99|100|ethanol|7.8|10| | [pka]
10.75±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
dBRD9-A is a potent BRD9 degrader that selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. It was shown to inhibit the growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model. | [Uses]
dBRD 9-A is a PROTAC which can selective degrade BRD9. dBRD 9-A improves the bromine domain binding profile and reduces the binding activity of the whole BET family[1]. | [storage]
Store at -20°C | [References]
[1] Remillard D, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743. DOI:10.1002/anie.201611281
[2] Ye ZHENG, et al. WO2022183056A1. 2022. |
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