| Hazard Information | Back Directory | [Uses]
Xeruborbactam (QPX7728) disodium is a potent, ultra-broad-spectrum boronic acid beta-lactamase inhibitor. Xeruborbactam disodium inhibits key serine and metallo beta-lactamases at a nano molar range[1]. | [Biological Activity]
QPX7728-OH disodium (compound 13) is a boronic acid β-lactamase inhibitor, exacted from WO2018005662A1, compound 13. QPX7728-OH disodium inhibits cleavage of Nitrocefin by purified class A, C and D enzymes, with Kis less than 0.1 μμ[1].
QPX7728-OH disodium potentiates Aztreonam and Tigemonam against strains expressing class A and class C enzymes, with MICs≤5 μg/mL. QPX7728-OH disodium potentiates Biapenem against strains expressing class A (KPC) or class D (OXA-48) carbapenemases, with MICs≤5 μg/mL[1]. | [References]
[1]. Scott Hecker, et al. Boronic acid derivatives and therapeutic uses thereof. WO2018005662A1. |
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