2173054-79-8

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2173054-79-8 Structure

Identification	Back Directory
[Name] Astegolimab
[CAS] 2173054-79-8
[Synonyms] Astegolimab Research Grade Astegolimab (DHF88301)

Chemical Properties	Back Directory
[form ] Liquid
[color ] Colorless to light yellow

Hazard Information	Back Directory
[Uses] Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody that blocks IL-33 signaling by targeting ST2, the IL-33 receptor. Astegolimab has the potential for chronic obstructive pulmonary disease (COPD) research[1].
[IC 50] ST2
[References] [1] Steven G Kelsen, et al. Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial. J Allergy Clin Immunol. 2021 Sep;148(3):790-798. DOI:10.1016/j.jaci.2021.03.044

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