| Hazard Information | Back Directory | [Description]
M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction. | [Uses]
M-525 is a first-in-class, highly potent, irreversible and covalent menin-MLL protein-protein interaction inhibitor. M-525 binds to menin with an IC50 of 3 nM and achieves low nanomolar potencies in cell growth inhibition and in suppression of MLL regulated gene expression in MLL leukemia cells. Anti-leukemia activity[1]. | [References]
[1] Xu S, et al. Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605. DOI:10.1002/anie.201711828 |
|
|