| Identification | Back Directory | [Name]
L-803,087 TRIFLUOROACETATE | [CAS]
217480-26-7 | [Synonyms]
L-803,087 TRIFLUOROACETATE
L-Arginine, N2-[4-(5,7-difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]-, methyl ester
N2-[4-(5,7-DIFLUORO-2-PHENYL-1H-INDOL-3-YL)-1-OXOBUTYL]-L-ARGININE METHYL ESTER TRIFLUOROACETATE | [Molecular Formula]
C25H29F2N5O3 | [MDL Number]
MFCD09037334 | [MOL File]
217480-26-7.mol | [Molecular Weight]
485.53 |
| Chemical Properties | Back Directory | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 100 mM in DMSO and to 100 mM in ethanol | [form ]
Powder | [pka]
14.54±0.46(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Somatostatin receptors are often overexpressed in tumours and are potential therapeutic targets. Somatostatin receptor agonists can be used to study signaling pathways related somatostatin receptor. L 803087 is a somatostatin sst4 receptor agonist. | [Biological Activity]
Potent and selective somatostatin sst 4 receptor agonist. K i values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst 4 , sst 1 , sst 2 , sst 3 and sst 5 receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice in vivo . | [in vivo]
L-803087 (5 nmol) is doubled seizure activity in wild-type mice on average. Interestingly, this effect is blocked by 3 nmol Octreotide. In hippocampal slices from wild-type mice, Octreotide (2 μM) does not modify AMPA-mediated synaptic responses while facilitation occurred with L-803087 (2 μM)[2]. |
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| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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