| Identification | Back Directory | [Name]
SCH00013 | [CAS]
217963-18-3 | [Synonyms]
SCH00013
SCH 00013;SCH00013
Benzonitrile, 4-[2-[3,6-dihydro-4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-1(2H)-pyridinyl]-1-hydroxyethyl]-
4-[1-hydroxy-2-[4-(6-oxo-4,5-dihydro-1~{H}-pyridazin-3-yl)-3,6-dihydro-2~{H}-pyridin-1-yl]ethyl]benzonitrile | [Molecular Formula]
C18H20N4O2 | [MOL File]
217963-18-3.mol | [Molecular Weight]
324.38 |
| Chemical Properties | Back Directory | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.52±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
SCH00013 is a cardiotonic that primarily increases the sensitivity of muscle fibers to Ca++. | [References]
[1] Sugawara H et al. A novel cardiotonic agent SCH00013 acts as a Ca++ sensitizer with no chronotropic activity in mammalian cardiac muscle.
J Pharmacol Exp Ther. 1998 Oct;287(1):214-22. PMID:9765340
[2] Tadano N et al. SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure. J Pharmacol Sci. 2005 Jan;97(1):53-60. DOI:10.1254/jphs.fp0040654
[3] Endoh M et al. Pharmacology of SCH00013: a novel Ca2+ sensitizer. Cardiovasc Drug Rev. 2001 Winter;19(4):345-66. DOI:10.1111/j.1527-3466.2001.tb00075.x |
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