| Identification | Back Directory | [Name]
2-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID | [CAS]
21801-79-6 | [Synonyms]
ASISCHEM C71528
BUTTPARK 9\05-56
3-Carboxy-2-methylimidazo[1,2-a]pyridine
2-methyl-3-imidazo[1,2-a]pyridinecarboxylate
2-a)pyridine-3-carboxylicacid,2-methyl-imidazo(
2-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID
IMidazo[1,2-a]pyridine-3-carboxylic acid, 2-Methyl-
2-Methylimidazo[1,2-a]pyridine-3-carboxylic acid ,97%
2-Methylimidazoó1,2-a!pyridine-3-carboxylic acid, 97%
2-methylimidazo[1,2-a]pyridine-3-carboxylic acid hydrochloride | [Molecular Formula]
C9H8N2O2 | [MDL Number]
MFCD00244615 | [MOL File]
21801-79-6.mol | [Molecular Weight]
176.17 |
| Chemical Properties | Back Directory | [Melting point ]
140 °C | [Boiling point ]
170°C | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
-0.55±0.41(Predicted) | [Appearance]
White to off-white Solid |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38-36-22 | [Safety Statements ]
26-36/37/39-22 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29339900 | [Toxicity]
mouse,LD50,intraperitoneal,600mg/kg (600mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: IRRITABILITYBEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY),Journal of Medicinal Chemistry. Vol. 12, Pg. 122, 1969. |
| Hazard Information | Back Directory | [Chemical Properties]
Pink solid | [Synthesis]
To a stirred ethyl 2-methylimidazo[1,2-a]pyridine-3-carboxylate (2.00 g) solution of ethanol/water (1:1, 30 mL) was added lithium hydroxide (4.00 g) and the reaction was stirred for 4 hours at room temperature. Upon completion of the reaction, the reaction mixture was concentrated to half of the original volume, followed by the slow addition of 6N hydrochloric acid at 0 °C and adjusting the pH to 6. The precipitated solid was collected by filtration and dried in a vacuum oven to afford 2-methylimidazo[1,2-a]pyridine-3-carboxylic acid (1.53 g, 88% yield) as an off-white solid.ESI-MS analysis showed the molecular ion peaks as 177 [M + H]+. | [References]
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 17, p. 7525 - 7545
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 15, p. 4223 - 4232
[3] Farmaco, Edizione Scientifica, 1982, vol. 37, # 1, p. 22 - 35
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 1870 - 1873
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5293 - 5305 |
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