| Identification | Back Directory | [Name]
RPR 203494 | [CAS]
218160-26-0 | [Synonyms]
RPR 203494
Methanone, [trans-2-[5-[2-(cyclopropylamino)-4-pyrimidinyl]-4-(4-fluorophenyl)-1H-imidazol-2-yl]-5-methyl-1,3-dioxan-5-yl]-4-morpholinyl- | [Molecular Formula]
C26H29FN6O4 | [MOL File]
218160-26-0.mol | [Molecular Weight]
508.54 |
| Hazard Information | Back Directory | [Description]
RPR203494 is a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency. | [Uses]
RPR203494 is a potent inhibitor against CYP isozymes. RPR203494 shows inhibition against p38 kinase with an IC50 value of 9 nM and an EC50 value of 60 nM. RPR203494 demonstrates an inhibition of hepatic Cytochrome P450. RPR203494 is promising for research of rheumatoid arthritis (RA)[1]. | [References]
[1] Collis AJ, et al. RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency. Bioorg Med Chem Lett. 2001 Mar 12;11(5):693-6. DOI:10.1016/s0960-894x(01)00034-8 |
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