| Identification | Back Directory | [Name]
N-(t-butyl ester-PEG3)-N-bis(PEG3-azide) | [CAS]
2182602-15-7 | [Synonyms]
XUN 02157
N-(Boc-PEG3)-N-bis(PEG3-azide)
N-(t-butyl ester-PEG3)-N-bis(PEG3-azide) | [Molecular Formula]
C29H57N7O11 | [MDL Number]
MFCD31561135 | [MOL File]
2182602-15-7.mol | [Molecular Weight]
679.81 |
| Hazard Information | Back Directory | [Description]
N-(t-butyl ester-PEG3)-N-bis(PEG3-azide) is developed by BroadPharm as a branched PEG linker with two terminal azide group and a t-butyl ester. The azide groups is very reactive with alkyne such as DBCO, BCN and propargyl reagnet via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under mild acidic conditions. | [Uses]
N-(Boc-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Boc-PEG3)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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