| Identification | Back Directory | [Name]
Imidazo[1,2-b]pyridazine-3-carboxamide, N-[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]-6-[(3R)-3-piperidinylamino]- | [CAS]
2183503-33-3 | [Synonyms]
IRAK4-IN-17
Imidazo[1,2-b]pyridazine-3-carboxamide, N-[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]-6-[(3R)-3-piperidinylamino]- | [Molecular Formula]
C17H20F2N8O | [MOL File]
2183503-33-3.mol | [Molecular Weight]
390.39 |
| Hazard Information | Back Directory | [Uses]
IRAK4-IN-17 (Compound 5) is a potent IRAK4 inhibitor with the IC50 of 1.3 nM[1]. IRAK4-IN-17 can be used in large B-cell lymphoma (DLBCL) research[1]. | [IC 50]
IRAK4: 1.3 nM (IC50) | [References]
[1] Yun Chen, et al. Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma. Eur J Med Chem. 2020 Mar 15;190:112092. DOI:10.1016/j.ejmech.2020.112092 |
|
|