| Identification | Back Directory | [Name]
1-Deoxysphingosine (m18:1(14Z)) | [CAS]
2190487-94-4 | [Synonyms]
1-Deoxysphingosine (m18:1(14Z)) | [Molecular Formula]
C18H37NO | [MDL Number]
MFCD34600137 | [MOL File]
2190487-94-4.mol | [Molecular Weight]
283.49 |
| Hazard Information | Back Directory | [Description]
1-Deoxysphingosine (m18:1(14Z)) is an atypical sphingolipid that contains a double bond at the n-4 (14Z) native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 It lacks the C1-hydroxyl group necessary for canonical degradation, however, it is metabolized by the cytochrome P450 (CYP) subfamilies CYP4A and CYP4F in MEF cells.2
| [References]
1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemical structure of native 1-deoxysphingosine J. Lipid Res. 57(7),1194-1203(2016).
2. Alecu, I., Othman, A., Penno, A., et al. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway J. Lipid Res. 58(1),60-71(2017). |
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| Company Name: |
Enzo Biochem Inc
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| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
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