21911-75-1

20059-60-3

21911-75-1

General procedure for the synthesis of N-phenyl-N-methylglycine hydrochloride from methyl 2-(methyl(phenyl)amino)acetate: c) Preparation of N-phenyl-N-methylglycine hydrochloride Methyl 2-(methyl(phenyl)amino)acetate (0.80 g, 4.46 mmol) obtained from step b was dissolved in 10% aqueous hydrochloric acid (20 mL) and the reaction was stirred under reflux conditions for 4 hours. After completion of the reaction, water was removed by distillation under reduced pressure and the resulting residue was dried under vacuum to give the crude product (0.81 g) as a solid. The crude product was washed with acetone and again dried under vacuum to give purified N-phenyl-N-methylglycine hydrochloride (0.65 g, 72% yield). Product characterization data: 1H NMR (400 MHz, DMSO-d6) δ: 7.15 (m, 2H), 6.65 (m, 3H), 4.08 (s, 2H), 3.71 (s, 3H), 2.96 (s, 3H).