| Identification | Back Directory | [Name]
2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]- | [CAS]
2191110-79-7 | [Synonyms]
2-Propen-1-one, 1-[7-(phenylmethyl)-2,7-diazaspiro[4.4]non-2-yl]- | [Molecular Formula]
C17H22N2O | [MOL File]
2191110-79-7.mol | [Molecular Weight]
270.37 |
| Hazard Information | Back Directory | [Uses]
EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol[1]. | [References]
[1] Shao Q, et al. Targeted Protein Localization by Covalent 14-3-3 Recruitment. J Am Chem Soc. 2024 Sep 11;146(36):24788-24799. DOI:10.1021/jacs.3c12389 |
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